I'm an Associate Principal Scientist at AstraZeneca's Centre for Genomic Research based in London. A mathematical engineer turned computational biologist, I work at the meeting point of single-cell genomics and population genetics: I both develop methods to map genetic effects on gene expression in single cells, such as CellRegMap and SAIGE-QTL, and apply them to population-scale cohorts such as TenK10K and HipSci. More recently I use genome-wide perturbation screens to study the precise mechanisms by which genes act in specific cellular types and states. My goal is to understand how natural genetic variation and experimental perturbations shape cells, to reveal mechanism and help find new drug targets.
Previously an EMBO postdoctoral fellow at the Garvan Institute in Sydney and a postdoc at the Wellcome Sanger Institute; PhD in Statistical Genetics from the University of Cambridge and EMBL-EBI.
Read my CV Publications
Nature, 2026 · The first phase of TenK10K: matched whole-genome and single-cell RNA sequencing from 1,925 individuals, mapping common and rare variant effects across 28 immune cell types.
medRxiv (preprint), 2024 · SAIGE-QTL: a scalable mixed-model tool that maps eQTLs directly from single cells, without collapsing to pseudobulk, and adds set-based tests for rare variants.
Nature Reviews Genetics, 2023 · A review of single-cell genetic studies so far, and the challenges and opportunities ahead for the field.
30 October 2026 · How common and rare genetic variants shape gene expression across 28 immune cell types, in nearly 2,000 people.
